https://doi.org/10.4081/jlimnol.2021.2029
Presence of carbepenemase-producing Enterobacteriaceae in the River Lambro basin, Italy: might sediment represent an important resistance reservoir?
Submitted: 4 May 2021
Accepted: 2 July 2021
Published: 20 July 2021
Accepted: 2 July 2021
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
In the last years, the rapid spread in anthropized ecosystems of pathogens which are resistant to carbapenem antibiotics has raised great concern. In this study, KPC-producing Klebsiella pneumoniae was found in the River Lambro in June 2019, whereas KPC-producing Klebsiella oxytoca and Citrobacter braakii were identified in untreated wastewaters. Susceptibility profiles indicated resistance to imipenem, ertapenem and meropenem. Different carbapenamase genes (blaKPC, blaNDM, blaVIM, blaOXA-48) were also found in the River Lambro, although not associated to living bacteria. The presence of a wide set of carbapenemase genes and resistant pathogens show that river sediments could act as a reservoir of antibiotic resistance potentially threatening human health.
Bonomo RA, Burd EM, Conly J, Limbago BM, Poirel L, Segre JA, Westblade LF, 2018. Carbapenemase-Producing Organisms: A Global Scourge. Clin. Infect. Dis. 66:1290–1297.
DOI: https://doi.org/10.1093/cid/cix893
Caltagirone M, Nucleo E, Spalla M, Zara F, Novazzi F, Marchetti VM, Piazza A, Bitar I, Cicco M De, Paolucci S, Pilla G, Migliavacca R, et al., 2017. Occurrence of extended spectrum β-lactamases, KPC-Type, and MCR-1.2-producing enterobacteriaceae from wells, river water, and wastewater treatment plants in Oltrepò Pavese area, Northern Italy. Front. Microbiol. 8:1–12.
DOI: https://doi.org/10.3389/fmicb.2017.02232
Izdebski R, Baraniak A, Zabicka D, Sekowska A, Gospodarek-Komkowska E, Hryniewicz W, Gniadkowski M, 2018. VIM/IMP carbapenemase-producing enterobacteriaceae in Poland: Epidemic Enterobacter hormaechei and Klebsiella oxytoca lineages. J. Antimicrob. Chemother. 73:2675–2681.
DOI: https://doi.org/10.1093/jac/dky257
Khan FA, Hellmark B, Ehricht R, Söderquist B, Jass J, 2018. Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden. Eur. J. Clin. Microbiol. Infect. Dis. 37:2241–2251.
DOI: https://doi.org/10.1007/s10096-018-3365-9
Kümmerer K, 2004. Resistance in the environment. J. Antimicrob. Chemother. 54:311–320.
DOI: https://doi.org/10.1093/jac/dkh325
Kwong JC, Lane CR, Romanes F, Silva AG da, Easton M, Cronin K, Waters MJ, Tomita T, Stevens K, Schultz MB, Baines SL, Sherry NL, et al., 2018. Translating genomics into practice for real-time surveillance and response to carbapenemase-producing Enterobacteriaceae: Evidence from a complex multi-institutional KPC outbreak. PeerJ 2018.
DOI: https://doi.org/10.7717/peerj.4210
Liu L, Qin L, Hao S, Lan R, Xu B, Guo Y, Jiang R, Sun H, Chen X, Lv X, Xu J, Zhao C, 2020. Lineage, antimicrobial resistance and virulence of Citrobacter spp. Pathogens 9:1–21.
DOI: https://doi.org/10.3390/pathogens9030195
Mills MC, Lee J, 2019. The threat of carbapenem-resistant bacteria in the environment: Evidence of widespread contamination of reservoirs at a global scale. Environ. Pollut. 255:113143.
DOI: https://doi.org/10.1016/j.envpol.2019.113143
Perilli M, Bottoni C, Pontieri E, Segatore B, Celenza G, Setacci D, Bellio P, Strom R, Amicosante G, 2013. Emergence of blaKPC-3-Tn4401a in Klebsiella pneumoniae ST512 in the municipal wastewater treatment plant and in the university hospital of a town in central Italy. J. Glob. Antimicrob. Resist. 1:217–220.
DOI: https://doi.org/10.1016/j.jgar.2013.07.002
Proia L, Anzil A, Borrego C, Farrè M, Llorca M, Sanchis J, Bogaerts P, Balcázar JL, Servais P, 2018. Occurrence and persistence of carbapenemases genes in hospital and wastewater treatment plants and propagation in the receiving river. J. Hazard. Mater. 358:33–43.
DOI: https://doi.org/10.1016/j.jhazmat.2018.06.058
Rimoldi SG, Stefani F, Gigantiello A, Polesello S, Comandatore F, Mileto D, Maresca M, Longobardi C, Mancon A, Romeri F, Pagani C, Cappelli F, et al., 2020. Presence and infectivity of SARS-CoV-2 virus in wastewaters and rivers. Sci. Total Environ. 744:140911.
DOI: https://doi.org/10.1016/j.scitotenv.2020.140911
Shen Z, Gao Q, Qin J, Liu Y, Li M, 2020. Emergence of an NDM-5-Producing Hypervirulent Klebsiella pneumoniae Sequence Type 35 Strain with Chromosomal Integration of an Integrative and Conjugative Element, ICEKp1. Antimicrob. Agents Chemother. 64:e01675-19.
DOI: https://doi.org/10.1128/AAC.01675-19
Viganò L, Mascolo G, Roscioli C, 2015. Emerging and priority contaminants with endocrine active potentials in sediments and fish from the River Po (Italy). Environ. Sci. Poll. Res. 22:14050–14066.
DOI: https://doi.org/10.1007/s11356-015-4388-8
Viganò L, Loizeau JL, Mandich A, Mascolo G, 2016. Medium- and long-term effects of estrogenic contaminants on the middle River Po fish community as reconstructed from a sediment core. Arch. Environ. Contam. Toxicol. 71:454–472.
DOI: https://doi.org/10.1007/s00244-016-0315-3
Wyres KL, Holt KE, 2018. Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria. Curr. Opin. Microbiol. 45:131–139.
DOI: https://doi.org/10.1016/j.mib.2018.04.004
How to Cite
Rimoldi, Sara Giordana, Francesca Romeri, Anna Gigantiello, Cristina Pagani, Luigi Viganò, Annunziata Calvagna, Alessandro Tamoni, Mafalda Maresca, Maria Rita Gismondo, and Fabrizio Stefani. 2021. “Presence of Carbepenemase-Producing Enterobacteriaceae in the River Lambro Basin, Italy: Might Sediment Represent an Important Resistance Reservoir?”. Journal of Limnology 80 (3). https://doi.org/10.4081/jlimnol.2021.2029.
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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